李越中

电话：0531-88564288传真：E-Mail：lilab@sdu.edu.cn

教育背景

        起止时间             毕业院校         专业

博士  1990.9-1993.7          山东大学        微生物学

硕士  1987.9-1990.7         山东农业大学     真菌学

本科  1983.9-1987.7         山东大学         微生物学

工作经历

 起止时间               单位名称           专业技术职务

1993.7-1995.8  中科院沈阳应用生态研究所    博士后

1995.9至今     山东大学生命学院            副教授(1995年),教授(2000年)

科研方向

1.粘细菌多样性、生态与进化

2.粘细菌细胞群体行为及进化适应

3.抗肿瘤化合物埃博霉素及其生物工程改造

主持课题

1.2008-2012 粘细菌及其细胞行为社会性的进化适应、分子机制及其利用 国家杰出青年基金

2.2012-2016粘细菌细胞群体行为对海洋生境适应的进化基因组分析      国家自然基金重点项目

3.2013-2016 能源与医药产品模块化设计合成                         863子课题

代表性论文

1.Wang Y, Li X, Zhang W, Zhou X,Li YZ*. groEL2, but not groEL1, is required for the biosynthesis of the secondary metabolite myxovirescin in Myxococcusxanthus DK1622. Microbiology. 2014. 160, 488-495.

2.Shu-guang Li, Lin Zhao, Kui Han, Peng-fei Li, Zhi-feng Li, Hong Liu, Zhi-hong Liu,Yue-zhong Li*. Diversity of epothilone producers among Sorangium strains in producer-positive soil habitats. MicrobBiotechnol, 2014, 7(2), 130-141.

3.Kui Han, Zhi-feng Li, Ran Peng, Li-ping Zhu, Tao Zhou, Lu-guang Wang, Shu-guang Li, Xiao-bo Zhang, Wei Hu, Zhi-hong Wu, Nan Qin andYue-zhong Li*. Extraordinary expansion of a Sorangiumcellulosum genome from an alkaline milieu.Sci Rep, 2013, 3, 2101.

4.Peng-fei Li, Shu-guang Li, Zhi-feng Li, Lin Zhao, Ting Wang, Hong-wei Pan, Hong Liu, Zhi-hong Wu andYue-zhong Li*. Co-cultivation of Sorangiumcellulosum strains affects cellular growth and biosynthesis of secondary metabolite epothilones. FEMS MicrobiolEcol, 2013, 85, 358-368.

5.WJ Han, JY Gu, HH Liu, FC Li, ZH Wu,YZ Li*. An extra peptide within the catalytic module of a beta-agarase affects the agarose degradation pattern. J BiolChem, 2013, 288(13): 9519–9531.

6.Y Wang, WY Zhang, Z Zhang, J Li, ZF Li, ZG Tan, TT Zhang, ZH Wu, H Liu,YZ Li*. Mechanisms involved in the functional divergence of duplicated GroELchaperonins in Myxococcusxanthus DK1622. PLoS Genet, 2013, 9(2): e1003306.

7.J Feng, XJ Chen, X Sun, N Wang,YZ Li*.Characterization of the replication origin of the myxobacterial self-replicative plasmid pMF1. Plasmid, 68(2012): 105–112.

8.DM Jiang, C Kato, XW Zhou, ZH Wu, T Sato,YZ Li*. Phylogeographic separation of marine and soil myxobacteria at high levels of classification. The ISME Journal, 2010, 4: 1520-1530.

9.HW Pan, ZG Tan, H Liu, ZF Li, CY Zhang, CY Li, J Li,YZ Li*. Hdsp, a horizontally transferred gene required for social behavior and halotolerance in salt-tolerant Myxococcusfulvus HW-1. The ISME Journal, 2010, 4: 1282-1289.

10.J Li, Y Wang, CY Zhang, WY Zhang, DM Jiang, ZH Wu, H Liu,YZ Li*. Myxococcusxanthus viability depends on GroEL supplied by either of two genes, but the paralogs have different functions during heat shock, predation, and development. J Bacteriol, 2010, 192(7): 1875-1881.

专利  

1.一株耐碱纤维堆囊菌及其在制备埃博霉素中的应用，授权时间：2010.10，专利号：ZL 2008 1 0157515.7。

2.埃博霉素苷类化合物和以其为活性成分的组合物及其应用，授权时间：2014.01，日本专利特许第5462268号。